Endocrine Abstracts

BackgroundCardiac autonomic neuropathy (CAN) is a serious complication of diabetes mellitus (DM) that is strongly associated with increased risk of cardiovascular mortality. The significance of CAN has not been fully appreciated. Treatment of CAN includes physical activity.AimTo detect CAN status and measure the influence of physical activity on the autonomic nervous system using cardiovascular autonomic refl...

Background and aim: The role of derangements of nitric oxide (NO) metabolism in the pathogenesis of complications of type 1 diabetes mellitus (T1D) is not sufficiently clear. There is little data on simultaneous measurements of NO metabolites nitrite and nitrate (NO2/NO3) in urine and serum in T1D. Data about the measurement of NO production by electronparamagnetic spectroscopy (EPR) in whole blood in T1D were never published. To fill this gap we have cha...

Background: Physical activity is the first-line treatment in type 2 diabetes. Interval walking training has demonstrated good tolerability and more pronounced positive effects on physical fitness and metabolism in type 2 diabetes, compared to continuous walking. However, the effects of interval walking on vascular health markers, such as albuminuria, has not been extensively studied. Type 2 diabetes is associated with derangements in leptin/adiponectin axis, which might predis...

BackgroundDiabetic retinopathy is the leading cause of blindness in working-age adults in developed world. Derangements of ubiquitine-proteasome system and telomere length have been associated with microangiopathy in diabetes. Until now, limited data are available on above markers in diabetic retinopathy in type 1 diabetes (T1D).AimThe aim of this work was to compare serum proteasome concentration and telomer...